Bryan Mbeumo opened the scoring for the Red Devils after just two minutes after picking up a superb Amad Diallo through ball and clipping the ball past an advancing Giorgi Mamardashvili.

Cody Gakpo threatened to spoil their afternoon with a 78th minute header that beat Senne Lammens in the United goal, but Maguire rose highest at the back post to head home a vital 84th minute winner - to hand Ruben Amorim his first successive wins as manager, after they beat Sunderland 2-0 last week.

The result left United in ninth place on the league standings with 13 points from eight games, and Liverpool in fourth place with 15 points - four adrift of league leaders Arsenal.

After the game, Amorim told the club's press: "Firstly, I know what it means to everyone here.

"I try to make it the same thing because for me to win against a fourth division team is always the same responsibility.

"We need to address every game like it is Liverpool away so that is my focus. But, of course, I know that it is a different game. We have not won there for a while, so we want to change that.

"The most important thing and I think I have said it one million times is the way we are going to play the game. Then the rest, we have talent to win games, but we need to be aggressive.

"We need to be different to what we showed against Manchester City, for example. So, if we are aggressive and focused on the task, we can win any game."

Reds boss Arne Slot added on NBC: "What I saw today is the players who were starting were able to create already a quite a lot of chances in the first half and the players I brought in created even more. But that also has to do with all the effort we put it in the first half.

"Florian Wirtz came in and was again creating a lot. Hugo Ekitike came in and was very close to scoring a goal. Federico Chiesa did really well and Jeremie Frimpong came in and had, he should've had an assist because normally Cody Gakpo scores a ball like that so I don't think the focus should be on them, the focus should be on me, on us, the team, whoever you want to focus on, but everyone is giving it all and that's what people expect from us. That's what the players are doing."

Elsewhere, Tottenham missed out on the opportunity to move second in the Premier League standings after losing 2-1 to Aston Villa at home on Sunday afternoon.

Thomas Frank's side came into this clash seven games unbeaten but were dealt a blow when they lost Cristian Romero to injury during the warm-up. He was replaced by Kevin Danso.

Nevertheless, they started the tie the more adventurous of the two sides and were ahead after just five minutes at the Tottenham Hotspur Stadium through Rodrigo Bentancur.

But the home team failed to build on the lead and were pegged back when Morgan Roger fired home with his 37th minute equaliser.

Emi Buendia's 77th minute effort then sealed all three points for Unai Emery's team, who ended their afternoon in 11th place with 12 points from their opening eight games.

Spurs currently occupy sixth place with 14 points.

Speaking after the game, Frank told reporters: "Minor doctor issue, nothing big.

On whether Romero would be available for the midweek Champions League clash against Monaco, the Spurs boss added: "I don't know. He could be, he couldn't. I just don't know."

On the overall performance, Frank said: "I think the way the game panned out was exactly how I expected it to be, if I'm honest.

"A very even game against a very good Villa team, set up very well by Unai, where I think we performed quite well.

“What is, maybe not through the roof, I'm thinking what is through the roof is that totally dominating Villa, which has been a very good team in the last couple of seasons, clearly a very good team with good players.”

Emery expressed his pride with the victory, telling his club's website: "I'm very, very proud of every Aston Villa supporter, they are here with us, they support us and they were helping us.

"And, of course, I'm very proud of the work we did today. The players focused on the match, 90 minutes strongly. Even when we were losing, we didn't lose our gameplan and progressively got better, feeling better.

"It was really a very good win."

Sunday Premier League results wrap - Harry Maguire heads Man Utd to victory as Villa see off Spurs